Levaquin Drug Interactions

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Generic name: Levofloxacin
Brand name: Levaquin

DRUGS Class and Mechanism: Levofloxacin is an antibiotic to treat bacterial infections. Many common infections in humans are caused by bacteria. Bacteria can grow and multiply, infecting different parts of the body. Medicines that control and eradicate these bacteria are called antibiotics. Levofloxacin is an antibiotic that prevents bacterial growth by inhibiting the reproduction and repair of their genetic material, DNA. It is in a class of antibiotics called fluoroquinolones, a class that includes ciprofloxacin (Cipro), norfloxacin (Noroxin), ofloxacin (Floxin), trovafloxacin (Trovan), and lomefloxacin (Maxaquin). The FDA has approved levofloxacin in December 1996.

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Generic Available: No

PRESCRIPTION: Yes

Presentation: Tablets: 250, 500 and 750 mg, oral solution 25 mg / mL Injection: 5 mg / ml and 25 mg / ml

STORAGE: Levofloxacin should be stored between 15-30 C (59-86 F)

Hint: Levofloxacin is used to treat infections of the sinuses, skin, lungs, ears, airways, bones and joints caused by susceptible bacteria. Levofloxacin is also frequently used to treat urinary infections, including those (resistant to other antibiotics, as well as prostatitis prostate infection). Levofloxacin is effective in treating infectious diarrhea caused by the bacterium E. coli, Campylobacter jejuni, and shigella bacteria. Levofloxacin may also be used to treat various obstetric infections, including mastitis (infection of the chest).

Dosage: The usual dose is 250-750 mg once daily for 5-60 days depending on the type of infection. It is important to take oral formulations at least 2 hours before or 2 hours after an antacid or mineral supplement containing iron, calcium, zinc or magnesium, as these bind levofloxacin and prevent its absorption into the body.

INTERACTIONS: iron, calcium, zinc, magnesium or can attach to levofloxacin and other fluoroquinolones and prevent their absorption by the intestine into the blood. Therefore, the products (eg, antacids) containing iron, calcium, zinc or magnesium must be taken at least 2 hours before or 2 hours after levofloxacin. Other drugs that contain these minerals and may even interact with levofloxacin include sucralfate (Carafate) and didanosine (Videx, Videx EC).

Taking anti-inflammatory drugs (NSAIDs) to levofloxacin may increase the risk of CNS stimulation, causing more excitement. There have been changes in blood sugar (increases and decreases) in patients treated with fluoroquinolones and antidiabetic. Fluoroquinolones may increase blood levels of theophylline (Theodur), cyclosporine (Sandimmune, Neoral), and the effect of warfarin (Coumadin).

PREGNANCY: Levofloxacin is not recommended for pregnant women since levofloxacin causes joint and bone deformities in juvenile animals of several species.

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