Naproxen 500mg

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GENERIC NAME: naproxen
Brand Name: Anaprox, Naprelan, Naprosyn, Aleve

DRUGS Class and Mechanism: Naproxen belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) and several others. These drugs are used for the management of mild to moderate pain, fever and inflammation. They work by reducing levels of prostaglandins, chemicals that are responsible for pain, fever and inflammation. Naproxen blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. In consequence, inflammation, pain and fever are reduced. Naproxen has been approved by the FDA in December 1991.

PRESCRIPTION: Yes (Aleve, no)

Generic Available: Yes

PREPARATIONS:
Anaprox (tablets): 275 and 550 mg;
Naprosyn (tablets): 250, 375 and 500 mg;
Naprosyn Suspension 125 mg/5ml;
EC-Naprosyn: 375 mg
Aleve: 220 mg;
Naprelan (controlled-release tablets): 375 and 500 mg.

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STORAGE: Naproxen should be stored at room temperature: 15-30 C (59-86 F).

Hint: Naproxen is used for the treatment of mild to moderate pain, inflammation and fever.

Dosage: The usual adult dose is 250-500 mg twice daily using regular naproxen tablets. The usual dose for Naprelan controlled release tablets is 750 to 1000 mg once a day. For EC-Naprosyn, the usual dose is 375-500 mg twice a day. Naproxen should be administered with food to reduce stomach upset.

INTERACTIONS: Naproxen is associated with several suspected or probable interactions that affect the action of other drugs. The following examples are the interactions most common suspects.

Naproxen may increase blood levels of lithium (Eskalith) by reducing the excretion of lithium by the kidneys. increased levels of lithium may lead to lithium toxicity.

Naproxen may reduce the hypotensive effects of drugs against hypertension. This may occur because prostaglandins play a role in regulating blood pressure.

When naproxen is used in combination with methotrexate or aminoglycoside (eg, gentamicin), blood levels of methotrexate or aminoglycoside may increase, probably because the removal of the body is reduced. This can lead to more side effects methotrexate or aminoglycoside-related.

People who take oral anticoagulants or anticoagulants [for example, warfarin (Coumadin)] should avoid naproxen because naproxen also thins the blood, and excessive blood thinning may lead to bleeding.

Pregnancy: There are no studies of naproxen in pregnant women. Therefore, the naproxen is not recommended during pregnancy.

Breastfeeding: A small amount of naproxen is excreted in breast milk. Because the concentration in breast milk is small, breastfeeding while taking naproxen is probably not detrimental to the child.

SIDE EFFECTS: The most common side effects are rash naproxen, tinnitus, headache, dizziness, drowsiness, abdominal pain, nausea, diarrhea, constipation, heartburn, water retention and of breath

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