Pioglitazone Drug

To compare the role of drugs glibenclamide and pioglitazone in type 11 non-insulin diabetes mellitus patients

To compare the role of drug glibenclamide and pioglitazone in type 11 non-insulin-dependent diabetic patients.

Authors: Raj Kumar Chohan, Mashori Ghulam Rasool, Ghulam Rasool Bhurgri, Shamim-u-Rehman Mustafa DahriGhulam, Anis-u-Rehman.

Introduction: -

Diabetes is the Greek word for "siphon" one of which is the first term and involves many of the urine is made. The CRT "sweet" comes from a word Laton, "met" which means "honey" and was used because the urine was sweet (Wheeler, 2004)

ketaocidosis diabetes is a life threatening condition requiring hospitalization and treatment data. The recognition of this condition is almost important as even small delays can have an impact on survival (Nattrass, 2006). Hypoglycemia is involved in insulin-induced episodes of people with diabetes. Probably the most important limitation, patients treated with insulin to achieve glucose targets needed to prevent diabetic complications. The incidence of hypoglycemia reflects the current Mathod inadequancy of insulin leads delievery OT insulin levels too high, especially after eating some more food early night blindness and also a disease major risk factor for heart and stroke

(Heller, 2003).

TYPES OF SUGAR Diabetes

Type 1 diabetes (IDDM):

Type I diabetes in children of all ages, both sexes and all groups athenic. Type 1 diabetes usually occurs by mechanisms. It is most common metabolic condition in children and adolescents (Bui, 2004). Type1diabetes is characterized by immune-mediated destruction of pancreatic B cells causing insulin deficiency. This results in a common biochemical endpoint of the risk of hyperglycemia and ketoacidosis, but the clinical Presentaion varies, usually depending on the speed and degree of b-l'edchec cells (Lambert & Bingley. 2005).

Diabetes mellitus type II (NIDDM):

Type II diabetes is a complex metabolic disorder associated with b-cell dysfunction and with different degrees of insulin resistance major pathogenic factors of insulin resistance leading to type 2 diabetes and a decrease in insulin secretion that arise from abnormalities in the liver, skeletal muscle and pancreatic B cells (Charles & Clark, 1996).

Diabetes mellitus GESTATIONAL

:

Women who develop glucose intolerance in late pregnancy and women with previously undiagnosed diabetes.

Diabetes mellitus SECONDARY:

Secondary diabetes is caused by disease and pancreatic system endocrime, genetic disorders, or exposure to chemical agents.

Type I diabetes - formerly known as insluin dependent diabetes mellitus (IDDM) is characterized by destruction of pancreatic beta cells that produced inslulin

Type I diabetes - formerly called diabetes mellitus (IDDM) is characterized by destruction of pancreatic beta cells that produced insulin.Type-1 diabetes occurs most often in children and young adults, but it place may, at any age. (Anderson et al 2007).

Type-11 diabetes is not straight uprward. Pancreas does not produce sufficient insulin. The liver to release glucose too much, the muscle cells that are not easily take in glucose. (McCarren 2008)

Many genetic factors are involved in the development of new diabetes.Because genetic researchers are strong methodology to identify all candidate genes for non-in.